This display has a controller built into it with RAM buffering, so that almost no work is done by the microcontroller. The display can be used in two modes: 8-bit or SPI. For 8-bit mode, you'll need 8 digital data lines and 4 or 5 digital control lines to read and write to the display (12 lines total). SPI mode requires only 5 pins total (SPI data in, data out, clock, select, and d/c) but is slower than 8-bit mode.